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KMID : 0614620030410060438
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Korean Journal of Gastroenterology
2003 Volume.41 No. 6 p.438 ~ p.446
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Helicobacter pylori cagA Gene and Host Interleukin-1 Beta and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Gastric Carcinoma
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Lee Jae-Seung
Kim Gwang-Ha
Heo Jeong
Park Do-Youn
Jun Eun-Sook
Kang Dae-Hwan
Song Geun-Am
Cho Mong
Yang Ung-Seok
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Abstract
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Backgournd/Aims: Both Helicobacter pylori (H. pylori) cagA genotype and host interleukin-1 beta/interleukin-1 receptor antagonist (IL-1B/IL-1RN) gene polymorphisms play a role in determining the clinical consequences of H. pylori infection. In this study, we investigated H. pylori cagA genotype and host IL-1B/IL-1RN polymorphisms in Korean patients to clarify their involvement in the occurrence of gastric carcinoma.
Methods: The population comprised of 134 patients with H. pylori infection: 82 with gastric carcinoma and 52 with gastritis. The DNA was isolated from gastric biopsy sample and H. pylori cagA genotype was determined by PCR. The IL-1B-511 polymorphism was genotyped by PCR-RFLP and the IL-1RN polymorphism was analyzed.
Results: Infection with cagA+ H. pylori was not associated with an increased risk for gastric carcinoma. The IL-1B-511 *T carriers and IL-1RN *2 carriers did not show an increased risk for gastric carcinoma. Combining bacterial/host genotypes, cagA+/IL-1B-511 *T carriers and cagA+/IL-1RN *2 carriers showed no increased risk of gastric carcinoma. Classifying of gastric carcinoma into intestinal and diffuse type, the bacterial/host genotypes were also not associated with increased risk of each type.
Conclusions: Combined H. pylori cagA gene and host IL-1B/IL-1RN polymorphisms showed no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors might play more important roles in the development of gastric carcinoma in Korean.
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KEYWORD
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Interleukin-1, Receptors, interleukin-1, Interleukin-1 receptor antagonist, Polymorphism, Stomach neoplasms, Interleukin-1β
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